Duodote dose for adults and those over 90 lb is which of the following?

• A. 1.0 g atropine and 50 mg pralidoxime
• B. 3.0 g atropine and 900 mg pralidoxime
• C. 5.0 g atropine and 1200 mg pralidoxime
• D. 2.1 g atropine and 600 mg pralidoxime

Answer: (D)

Duodote is a fixed combination used to treat organophosphate poisoning, pairing an antimuscarinic (atropine) with an antidote (pralidoxime). Atropine reverses the muscarinic effects such as excessive secretions, bronchospasm, and slow heart rate, while pralidoxime reactivates acetylcholinesterase to address both muscarinic and nicotinic symptoms and help recovery of muscle strength.

For adults and those over about 90 pounds, the standard per-dose amount is about 2 mg of atropine together with 600 mg of pralidoxime. In practice, you give one dose and then repeat every few minutes (commonly every 5 minutes) as needed until you observe adequate atropinization, along with supportive care. The key idea is the fixed-dose combination that provides roughly 2 mg atropine and 600 mg pralidoxime per dose, with repeated dosing based on clinical response.

Other listed dosages either misstate the amounts or mix the units, which would not align with the typical fixed-dose formulation or with how responders titrate therapy in organophosphate poisoning.