Indications for Duodote include which of the following?

• A. Cyanide poisoning
• B. Organophosphate poisoning only
• C. Organophosphate poisoning, unknown cholinesterase poisoning, nerve agent exposure
• D. Pesticide contamination

Answer: (C)

Duodote is used for poisoning by cholinesterase inhibitors, which includes organophosphates and nerve agents. Its atropine component counters the muscarinic effects, while pralidoxime reactivates acetylcholinesterase, addressing the underlying mechanism of these poisons. Because of this, it’s indicated not only for known organophosphate poisoning but also when the specific agent isn’t known but is suspected to inhibit cholinesterase, and for nerve agent exposure. That’s why the option describing organophosphate poisoning, unknown cholinesterase poisoning, and nerve agent exposure best fits the indications. It wouldn’t be used for cyanide poisoning, and “pesticide contamination” is too vague to define an indication for this antidote.